Trial of Psilocybin versus Escitalopram for Depression
Psilocybin may have antidepressant properties, but direct comparisons between psilocybin and established treatments for depression are lacking.
Antidepressant
Comparative Efficacy of Racemic Ketamine and Esketamine for Depression
Intravenous ketamine appears to be more efficacious than intranasal esketamine for the treatment of depression.
Antidepressant Actions of Ketamine Engage Cell-Specific Translation via eIF4E
Sub-anaesthetic doses of ketamine, a noncompetitive N-methyl-d-aspartate receptor antagonist provide rapid and long-lasting antidepressant effects in these patients, but the molecular mechanism of these effects remains unclear.