About 60% of people with depression aren’t helped by the first antidepressant they try, and about 30% don’t respond to several attempts at treatment. Researchers still don’t know why so many don’t people respond well to “anti-depressants” such as SSRIs, SNRIs, etc. Treatment Reistant Depression can be defined as Depression that doesn’t respond to two (or more) different antidepressants from different classes.
