Science & Research

A Proof-of-Concept Study of Subanesthetic Intravenous Ketamine Combined With Prolonged Exposure Therapy Among Veterans With Posttraumatic Stress Disorder

Paulo R. Shiroma, MD; Paul Thuras, PhD; Joseph Wels, MD; Christopher Erbes, PhD; Shannon Kehle-Forbes, PhD; and Melissa Polusny, PhD Published 10 November 2020 | https://doi.org/10.4088/JCP.20l13406 Abstract Prolonged exposure (PE) is a gold-standard trauma-focused therapy; however, clinical trials of trauma-based therapies in the military and veteran populations showed that up to 50% of participants failed […]

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Neurocognitive impact of ketamine treatment in major depressive disorder: A review on human and animal studies

Camilla Crisanti, Paolo Enrico, Alessio Fiorentini, Giuseppe Delvecchio, Paolo Brambilla Published 29 July 2020 |  https://doi.org/10.1016/j.jad.2020.07.119 Abstract Background Most recent evidence support a rapid and sustained antidepressant effect of subanesthetic dose of intravenous ketamine in patients with major depressive disorder (MDD). However, clinical and animal studies investigating the effects of intravenous ketamine on specific functional

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The emergence of ketamine as a novel treatment for posttraumatic stress disorder

Adriana Feder, Sarah B. Rutter, Daniela Schiller, Dennis S.Charney Published 19 June 2020 | https://doi.org/10.1016/bs.apha.2020.05.004 Abstract A serious lack of effective pharmacotherapeutic interventions for posttraumatic stress disorder (PTSD) raises the urgent need for the development of novel treatments. Ketamine—a noncompetitive glutamate N-methyl-d-aspartate (NMDA) receptor antagonist in use for decades as an anesthetic and analgesic agent—has

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Comprehensive assessment of side effects associated with a single dose of ketamine in treatment-resistant depression

Elia E. Acevedo-Diaz, Grace W. Cavanaugh, Dede Greenstein, Christoph Kraus, Bashkim Kadriu, Carlos A. Zarate, Lawrence T. Park Published 10 November 2019 | https://doi.org/10.1016/j.jad.2019.11.028 Abstract Background: Concerns about ketamine for treating depression include abuse potential and the occurrence of psychotomimetic effects. This study sought to comprehensively assess side effects (SEs) associated with a single subanesthetic-dose

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