Science & Research

How effective is ketamine in the management of chronic neuropathic pain?

Jack Williams Shteamer, Mayson Augustus Callaway, Parth Patel & Vinita Singh Published Online 15 Oct 2019 | https://doi.org/10.2217/pmt-2019-0032 Abstract The effectiveness of ketamine in treating chronic neuropathic pain, however, remains a debated issue. A recent meta-analysis of double blind randomized controlled trials (DB-RCT) utilizing ketamine for chronic neuropathic pain revealed mixed results. Six studies were […]

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Resting-state brain functional connectivity in patients with chronic pain who responded to subanesthetic-dose ketamine

Yasushi Motoyama, Yoshitetsu Oshiro, Yumiko Takao, Hitoaki Sato, Norihiko Obata, Shinichiro Izuta, Satoshi Mizobuchi & Shigeyuki Kan  Published 9 September 2019 | https://doi.org/10.1038/s41598-019-49360-1  Abstract Ketamine has been used to treat chronic pain; however, it is still unknown as to what types of chronic pain is ketamine effective against. To identify the effect of administration of

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Augmenting the Treatment of PTSD with Ketamine—a Review

Or Duek, Benjamin Kelmendi, Robert H. Pietrzak & Ilan Harpaz-Rotem  Published 10 May 2019 | DOI 10.1007/s40501-019-00172-0 Abstract Purpose Posttraumatic stress disorder (PTSD) is a debilitating psychiatric disorder with a lifetime prevalence of 6.1% in the general adult population. Clinical guidelines for the treatment of PTSD suggest the use of trauma-focused psychotherapies such as prolonged

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Single, Repeated, and Maintenance Ketamine Infusions for Treatment-Resistant Depression: A Randomized Controlled Trial

Jennifer L. Phillips, Ph.D., Sandhaya Norris, M.D., Jeanne Talbot, M.D., Ph.D., Meagan Birmingham, M.A., M.B.A., Taylor Hatchard, Ph.D., Abigail Ortiz, M.D., Olabisi Owoeye, M.D., Lisa A. Batten, Ph.D., Pierre Blier, M.D., Ph.D. Published Online: 29 Mar 2019 | https://doi.org/10.1176/appi.ajp.2018.18070834 Objective: Subanesthetic ketamine doses have been shown to have rapid yet transient antidepressant effects in patients with

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Ketamine Infusions for Chronic Pain: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Orhurhu, Vwaire MD, MPH; Orhurhu, Mariam Salisu MD, MPH; Bhatia, Anuj MD, FRCPC; Cohen, Steven P. MD 13 March 2019 | doi: 10.1213/ANE.0000000000004185 Abstract BACKGROUND:  IV ketamine is widely used to treat patients with chronic pain, yet the long-term impact remains uncertain. We synthesized evidence from randomized control trials to investigate the effectiveness of IV

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Ketamine: A Paradigm Shift for Depression Research and Treatment

John H. Krystal, Chadi G. Abdallah, Gerard Sanacora, Dennis S. Charney, Ronald S. Duman Published online: 6 March 2019 | https://doi.org/10.1016/j.neuron.2019.02.005 Abstract Ketamine is the first exemplar of a rapid-acting antidepressant with efficacy for treatment-resistant symptoms of mood disorders. Its discovery emerged from a reconceptualization of the biology of depression. Neurobiological insights into ketamine efficacy

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