Ketamine

Comprehensive assessment of side effects associated with a single dose of ketamine in treatment-resistant depression

Elia E. Acevedo-Diaz, Grace W. Cavanaugh, Dede Greenstein, Christoph Kraus, Bashkim Kadriu, Carlos A. Zarate, Lawrence T. Park Published 10 November 2019 | https://doi.org/10.1016/j.jad.2019.11.028 Abstract Background: Concerns about ketamine for treating depression include abuse potential and the occurrence of psychotomimetic effects. This study sought to comprehensively assess side effects (SEs) associated with a single subanesthetic-dose […]

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How effective is ketamine in the management of chronic neuropathic pain?

Jack Williams Shteamer, Mayson Augustus Callaway, Parth Patel & Vinita Singh Published Online 15 Oct 2019 | https://doi.org/10.2217/pmt-2019-0032 Abstract The effectiveness of ketamine in treating chronic neuropathic pain, however, remains a debated issue. A recent meta-analysis of double blind randomized controlled trials (DB-RCT) utilizing ketamine for chronic neuropathic pain revealed mixed results. Six studies were

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Resting-state brain functional connectivity in patients with chronic pain who responded to subanesthetic-dose ketamine

Yasushi Motoyama, Yoshitetsu Oshiro, Yumiko Takao, Hitoaki Sato, Norihiko Obata, Shinichiro Izuta, Satoshi Mizobuchi & Shigeyuki Kan  Published 9 September 2019 | https://doi.org/10.1038/s41598-019-49360-1  Abstract Ketamine has been used to treat chronic pain; however, it is still unknown as to what types of chronic pain is ketamine effective against. To identify the effect of administration of

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New Hope for Treatment-Resistant Depression: Guessing Right on Ketamine

In the meantime, practitioners of this new kind of mental healthcare can use ketamine as their psychedelic agent; and some studies, such as the one Grant participated in, are even government funded. The Ketamine for Reduction of Alcoholic Relapse (Kare) study is a novel attempt to ease the huge burden on the NHS caused by alcohol-related illnesses.

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Augmenting the Treatment of PTSD with Ketamine—a Review

Or Duek, Benjamin Kelmendi, Robert H. Pietrzak & Ilan Harpaz-Rotem  Published 10 May 2019 | DOI 10.1007/s40501-019-00172-0 Abstract Purpose Posttraumatic stress disorder (PTSD) is a debilitating psychiatric disorder with a lifetime prevalence of 6.1% in the general adult population. Clinical guidelines for the treatment of PTSD suggest the use of trauma-focused psychotherapies such as prolonged

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Single, Repeated, and Maintenance Ketamine Infusions for Treatment-Resistant Depression: A Randomized Controlled Trial

Jennifer L. Phillips, Ph.D., Sandhaya Norris, M.D., Jeanne Talbot, M.D., Ph.D., Meagan Birmingham, M.A., M.B.A., Taylor Hatchard, Ph.D., Abigail Ortiz, M.D., Olabisi Owoeye, M.D., Lisa A. Batten, Ph.D., Pierre Blier, M.D., Ph.D. Published Online: 29 Mar 2019 | https://doi.org/10.1176/appi.ajp.2018.18070834 Objective: Subanesthetic ketamine doses have been shown to have rapid yet transient antidepressant effects in patients with

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