Ketamine

Ketamine Infusions for Chronic Pain: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Orhurhu, Vwaire MD, MPH; Orhurhu, Mariam Salisu MD, MPH; Bhatia, Anuj MD, FRCPC; Cohen, Steven P. MD 13 March 2019 | doi: 10.1213/ANE.0000000000004185 Abstract BACKGROUND:  IV ketamine is widely used to treat patients with chronic pain, yet the long-term impact remains uncertain. We synthesized evidence from randomized control trials to investigate the effectiveness of IV

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Ketamine: A Paradigm Shift for Depression Research and Treatment

John H. Krystal, Chadi G. Abdallah, Gerard Sanacora, Dennis S. Charney, Ronald S. Duman Published online: 6 March 2019 | https://doi.org/10.1016/j.neuron.2019.02.005 Abstract Ketamine is the first exemplar of a rapid-acting antidepressant with efficacy for treatment-resistant symptoms of mood disorders. Its discovery emerged from a reconceptualization of the biology of depression. Neurobiological insights into ketamine efficacy

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Double-blind, placebo-controlled, dose-ranging trial of intravenous ketamine as adjunctive therapy in treatment-resistant depression (TRD)

Maurizio Fava, Marlene P. Freeman, Martina Flynn, Heidi Judge, Bettina B. Hoeppner, Cristina Cusin, Dawn F. Ionescu, Sanjay J. Mathew, Lee C. Chang, Dan V. Iosifescu, James Murrough, Charles Debattista, Alan F. Schatzberg, Madhukar H. Trivedi, Manish K Jha, Gerard Sanacora, Samuel T. Wilkinson, and George I. Papakostas Published 3 October 2018 | doi: 10.1038/s41380-018-0256-5

Double-blind, placebo-controlled, dose-ranging trial of intravenous ketamine as adjunctive therapy in treatment-resistant depression (TRD) Read More »

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