The Real Pros and Cons of Ketamine Infusions

Source: Ben Spielberg, TMS and Brain Health


Depression is the leading cause of disability worldwide and the primary mental health disorder that gives rise to suicidal tendencies.

Approximately two in three people who suffer from major depression eventually achieve lasting symptom remission with conventional antidepressants and therapy; the remaining one in three do not.

For people with TRD, debilitating anxiety, persistent PTSD, and chronic pain, ketamine infusion therapy offers several key advantages, including:


Ketamine infusions work very quickly — often within hours — to ease depressive symptoms. While researchers are still trying to pinpoint the mechanisms behind this powerful effect, they do know that ketamine stimulates a rapid increase in glutamate.

As the main neurotransmitter that encourages the growth of synapses in your brain, glutamate helps strengthen and restore vital neural connections and pathways in the regions of the brain that are most impaired by depression; these new connections help induce beneficial changes in brain circuit function.


Ketamine infusion therapy is still being studied, but research shows that it has a high rate of success when it comes to treating persistent depression.

Several studies indicate that over half of people with TRD achieve significant symptom relief after a single infusion, and many more find relief after two or three infusions.

An excellent efficacy rate is a major part of what makes ketamine infusion therapy so beneficial for people who haven’t been able to achieve lasting relief through traditional medical solutions.

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